Indole-3-carbinol (I3C)


Indole-3-carbinol, also known as I3C, is a breakdown product of the glucosinolate glucobrassicin found in cruciferous vegetables.

Research shows that indole-3-carbinol modulates estrogen metabolism. When added to breast cancer and prostate cancer cells in culture, I3C caused cell cycle arrest. Indole-3-carbinol has also been found to stop the formation of new blood vessels that feed tumors and fuel their growth – a process known as angiogenesis.

Indole-3-carbinol (I3C) - Found in:

Arugula, Broccoli, Brussels sprouts, Bok Choy, Cabbage, Cauliflower, Collards, Kohlrabi, Mustard Greens, Rutabagas, Sauerkraut, Watercress, Horseradish,
Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene. 2001;20(23):2927-2936.Meng Q, Goldberg ID, Rosen EM, Fan S. Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells. Breast Cancer Res Treat. 2000;63(2):147-152. Chang X, Tou JC, Hong C, et al. 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis. 2005;26(4):771-778.

About The Author

Kelley Herring, founder of Healing Gourmet, is a natural nutrition enthusiast with a background in biochemistry. Her passion is educating on how foods promote health and protect against disease and creating simple and delicious recipes for vibrant health and enjoyment.

Kelley Herring – who has written posts on Healing Gourmet.

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