Indole-3-carbinol (I3C)

Indole-3-carbinol (I3C)

Indole-3-carbinol, also known as I3C, is a breakdown product of the glucosinolate glucobrassicin found in cruciferous vegetables.

Research shows that indole-3-carbinol modulates estrogen metabolism. When added to breast cancer and prostate cancer cells in culture, I3C caused cell cycle arrest. Indole-3-carbinol has also been found to stop the formation of new blood vessels that feed tumors and fuel their growth --a process known as angiogenesis.

Find Indole-3-carbinol (I3C) in:

Arugula
Arugula, also called rocket, roquette, rugula and rucola, is a member of the Cruciferous family of vegetables...
Broccoli
A descendant of cabbage, broccoli is a member of the Cruciferous family of vegetables...
Brussels sprouts
Developed in Belgium several hundred years ago, and named for the country’s capital, Brussles sprouts are cruciferous vegetables and offshoots of cabbage...
Bok Choy
Bok choy is a Chinese cabbage and member of the cruciferous family of vegetables...
Cabbage
Cabbage isn't mundane...
Cauliflower
Cauliflower, like broccoli, is a member of the cruciferous family of vegetables...
Collards
Collards are a member of the Cruciferous family of vegetables and are believed to be among the oldest members of the cabbage family to be cultivated...
Kohlrabi
Kohlrabi, a member of the Brassica species and a crucifer, was believed to be enjoyed by the ancient Romans...
Mustard Greens
Mustard greens are a member of the cruciferous family of vegetables and the plant that produces mustard seeds...
Rutabagas
Rutabagas, or "Swedes", belong to the crucifer family...
Sauerkraut
Sauerkraut, which translates to “sour cabbage” in German, originated in China over 2,000 years ago where it is known as "kimchi"...
Watercress
Watercress is a member of the cruciferous family of vegetables...
Horseradish
Horseradish is a hot, pungent condiment made from a plant in the mustard family...

Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene. 2001;20(23):2927-2936.Meng Q, Goldberg ID, Rosen EM, Fan S. Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells. Breast Cancer Res Treat. 2000;63(2):147-152. Chang X, Tou JC, Hong C, et al. 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis. 2005;26(4):771-778.

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